QC-01–175 Datasheet DC Chemicals

Description	QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).QC-01–175 effected clearance of tau in frontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from neurons of healthy controls.QC-01–175 also rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated MAPT-knockout.
Cat.No	DC70723
Name	QC-01–175

Chemical Properties

CAS	2267290-96-8
Formula	C33H34N6O7
MW	626.659067630768
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. M Catarina Silva, et al. Elife. 2019 Mar 25;8:e45457.

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