R112 Datasheet DC Chemicals
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Cat.No DC8657
Name R112

Chemical Properties

CAS 575474-82-7
Formula C16H13FN4O2
MW 312.3
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:
In Vivo
In Vitro R112 blocks leukotriene C4 production and all proinflammatory cytokines tested. Its onset of action was immediate, and the inhibition was reversible. R112 is able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 potently, completely, and rapidly abrogated all mast cell activation cascades triggered by IgE receptor cross-linking.[1]
Kinase Assay
Cell Assay
Animal Administration

References

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