RAS activator compound 1 Datasheet DC Chemicals

Description	RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2.
Cat.No	DC12624
Name	RAS activator compound 1

Chemical Properties

CAS	1579978-17-8
Formula	C25H28CLN5O
MW	449.983
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

References 1. Howes JE, et al. Mol Cancer Ther. 2018 May;17(5):1051-1060. 2. Burns MC, et al. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6. View Related Products by Target Ras

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