RMC-4550 Datasheet DC Chemicals

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Cat.No	DC12051
Name	RMC-4550

Chemical Properties

CAS	2172651-73-7
Formula	C21H26CL2N4O2
MW	437.365
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:	IC50:0.583 nM (SHP2)[1].
In Vivo
In Vitro	RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20(9):1064-1073.

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