Refametinib (BAY86-9766) Datasheet DC Chemicals

Description	Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
Cat.No	DC7808
Name	Refametinib (BAY86-9766)

Chemical Properties

CAS	923032-37-5
Formula	C19H20F3IN2O5S
MW	572.34
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Iverson C, et al. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009 Sep 1;69(17):6839-47.

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