Rineterkib(ERK-IN-1;compound B) Datasheet DC Chemicals
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Cat.No DC57035
Name Rineterkib(ERK-IN-1;compound B)

Chemical Properties

CAS 1715025-32-3
Formula C26H27BRF3N5O2
MW 578.42
Storage -20

Biological activity

Description CAS NO.：1715025-32-3
Product Name：Rineterkib
Synonyms：Rineterkib;LTT-462;LTT 462;LTT462
EINECS:
Molecular Formula：C26H27BRF3N5O2
Molecular Weight：578.42
Target: RAF ERK1 ERK2
In Vivo ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice[1]. Animal Model: Calu-6 NSCLC xenograft tumor models in mice[1]. Dosage: 50, 75 mg/kg. Administration: Orally either daily (qd) or every other day (q2d) for 27 days. Result: Significantly reduced the tumor volume.
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. WO2018051306A1.
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