Riociguat (BAY 63-2521) Datasheet DC Chemicals
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Cat.No DC7267
Name Riociguat (BAY 63-2521)

Chemical Properties

CAS 625115-55-1
Formula C20H19FN8O2
MW 422.42
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:
In Vivo Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature in chronic treatment of hypoxic mice and MCT-injected rats[1].
In Vitro Riocigua stimulates the recombinant sGC concentration dependently from 0.1 to 100 μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism[1]. Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes[2].
Kinase Assay
Cell Assay
Animal Administration

References

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