Rp-8-bromo-Cyclic AMPS Datasheet DC Chemicals
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Cat.No DC11480
Name Rp-8-bromo-Cyclic AMPS

Chemical Properties

CAS 925456-59-3
Formula C10H12BRN5NAO5PS
MW 448.16531085968
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：925456-59-3
Product Name：8-bromo-adenosinecyclic3',5'-[hydrogen[P(R)]-phosphorothioate],monosodiumsalt
Synonyms：Rp-8-bromo-Cyclic AMPS (sodium salt);Rp-8-bromo-Cyclic AMPS;5'-cyclic monophosphorothioate;8-Bromoadenosine 3';RP-8-BR-CAMPS;8-BROMOADENOSINE 3';5'-CYCLIC MONOPHOSPHOROTHIOATE; RP-ISOMER;RP-8-BROMO-CAMPS;925456-59-3;Rp-8-bromo-cAMPS;Rp-isomer
EINECS:
Molecular Formula：C10H12BRN5NAO5PS
Molecular Weight：448.16531085968
Target:
In Vivo
In Vitro Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.
Kinase Assay
Cell Assay
Animal Administration

References

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