Ruxolitinib Phosphate Datasheet DC Chemicals
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Cat.No DC8309
Name Ruxolitinib Phosphate

Chemical Properties

CAS 1092939-17-7
Formula C17H21N6O4P
MW 404.37
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:
In Vivo Ruxolitinib (180 mg/kg, p.o.) reduces the tumor burden of mice inoculated with JAK2V617F-expressing cells without causing anemia or lymphopenia[1].
In Vitro Ruxolitinib (INCB018424) potently and selectively inhibits JAK2V617F-mediated signaling and proliferation. Ruxolitinib inhibits the growth of HEL cells with EC50 of 186 nM. Ruxolitinib markedly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell system, and inhibits hematopoietic progenitor cell proliferation in primary MPN patient samples[1].
Kinase Assay
Cell Assay
Animal Administration

References

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