Ensitrelvir dose-dependently inhibits intrapulmonary replication of SARS-CoV-2 in mice[2].
In Vitro
In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir shows the EC50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants. EC50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Kinase Assay
Cell Assay
Animal Administration
References
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