SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
Cat.No
DC8419
Name
SB-334867
Chemical Properties
CAS
792173-99-0
Formula
C17H13N5O2
MW
319.32
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
[1]. Smart D, et al. SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol. 2001 Mar;132(6):1179-82.
[2]. Rasmussen K, et al. The orexin-1 receptor antagonist SB-334867 blocks the effects of antipsychotics on the activity of A9 and A10 dopamine neurons: implications for antipsychotic therapy. Neuropsychopharmacology. 2007 Apr;32(4):786-92.
[3]. Azhdari-Zarmehri H, et al. Orexin receptor type-1 antagonist SB-334867 decreases morphine-induced antinociceptive effect in formalin test. Pharmacol Biochem Behav. 2013 Nov;112:64-70.
[4]. Rodgers RJ, et al. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur J Neurosci. 2001 Apr;13(7):1444-52.
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