SIRT7 inhibitor 97491 Datasheet DC Chemicals

Description	SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..
Cat.No	DC40782
Name	SIRT7 inhibitor 97491

Chemical Properties

CAS	1807758-81-1
Formula	C15H12CLN3O
MW	285.73
Storage	4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References

[1]. Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.

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