SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter.
Cat.No
DC9898
Name
SIS3
Chemical Properties
CAS
521984-48-5
Formula
C28H28CLN3O3
MW
489.99
Storage
References
[1]. Boudreau HE et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer. 2014 May 13;110(10):2569-82.
[2]. Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607.
[3]. Di Bernardini E et al. Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor β2 (TGF-β2) pathways. J Biol Chem. 2014 Feb 7;289(6):3383-93.
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