SP 141 Datasheet DC Chemicals

Description	SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM).
Cat.No	DC8599
Name	SP 141

Chemical Properties

CAS	1253491-42-7
Formula	C22H16N2O
MW	324.38
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Wei Wang , et al. Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice. Gastroenterology. 2014 Oct;147(4):893-902.e2. [2]. Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models. Nat Commun. 2014 Oct 1;5:5086.

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