SR-4370 Datasheet DC Chemicals
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Cat.No DC10788
Name SR-4370

Chemical Properties

CAS 1816294-67-3
Formula C17H18F2N2O
MW 304.13
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target: HDAC3:6 nM (IC50) HDAC1:130 nM (IC50) HDAC2:580 nM (IC50) HDAC8:2300 nM (IC50) HDAC6:3400 nM (IC50)
In Vivo
In Vitro SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. LIAO, Daiqing, et al. HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT. WO 2015153516 A1.
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