Substance P Datasheet DC Chemicals
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Cat.No DC10663
Name Substance P

Chemical Properties

CAS 33507-63-0
Formula C63H98N18O13S
MW 1347.63002
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：33507-63-0
Product Name：Substance P
Synonyms：Substance P;H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;Aminophenylacetylleucine;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;D-phenylglycyl-L-leucine;H-RPKPQQFFGLM-NH2;Neurokinin P;neuropeptide substance P;R-Phg-S-Leu;RPKPQQFFGLM;RPKPQQFFGLM-NH2;Sh-oligopeptide-73;GTPL3805;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(Substance P);Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-amine;(SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;CHEBI:80308;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;[3H]-substance P;ADNPLDHMAVUMIW-CUZNLEPHSA-N;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(substance P);Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2);RPKPQQFFGLM (modifications: C-terminal amide);H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-D-Phe-Gly-Leu-Met-NH2;BDBM50001450;tachykinin substance P (SP);SCHEMBL1116347;SCHEMBL20844802;HB2915;

C63H98N18O13S

;UNII-675VGV5J1D;Neurokinin P TFA;Substance p (1-11);12769-48-1;ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O;Neurokinin PNeurokinin P;GTPL3835;Substanz-P;33507-63-0;[125I]-substance P;[3H]SP (human, mouse, rat);[3H]-SP;GTPL2098;Neurokinin-1;ArgProLysProGlnGlnPhePheGlyLeuMet;AS-77493;EINECS 251-545-8;CCRIS 7229;[125I]SP (human, mouse, rat);AKOS024456424;NCGC00167123-01;Q411041;[125I]-SP;NS00074307;Neuropeptide sp-1;substance-P;11035-08-8;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2;675VGV5J1D;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.(Substance P);CHEMBL235363
EINEC:251-545-8
Molecular Formula：C63H98N18O13S
Molecular Weight：1347.63002
Target:
In Vivo
In Vitro The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].
Kinase Assay
Cell Assay
Animal Administration

References

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