2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：2451481-08-4 Product Name：Sulfopin Synonyms：Sulfopin;Sulfopin;Sulfopin EINECS: Molecular Formula：C11H20ClNO3S Molecular Weight：281.80
Target:
In Vivo
Sulfopin (40 mg/kg; p.o.; QD/BID for 7 days) regresses neuroblastoma in mice[1]. Sulfopin (20-40 mg/kg; i.p.; daily for 27 days) inhibits pancreatic cancer progression in mice[1]. Sulfopin (25-100 μM) blocks neuroblastoma in zebrafish[1]. Animal Model: Transgenic Th-MYCN mice[1] Dosage: 40 mg/kg Administration: Once a day (QD) or twice a day (BID) for 7 days Result: Sulfopin-treated QD mice showed a significant average increase in survival of 10 days, while Sulfopin-treated BID mice showed an even more pronounced average increase of 28 days.
In Vitro
MDA-MB-468 cells show the most pronounced sensitivity to Sulfopin (1, 2.5 μM; 4-8 days)[1]. Sulfopin (2 μM, HEK293 cells; 48 hours) downregulates Myc transcription[1]. Sulfopin (1, 2.5 μM; PATU-8988T cells; 4 days) shows a small but significant reduction in the number of synthesis (S)-phase cells and a corresponding increase of growth 1 (G1)-phase cells[1]. Cell Proliferation Assay[1] Cell Line: Kuramochi, MDA-MB-468, NGP, NBL-S, MDA-MB-468 cells Concentration: 1, 2.5 μM Incubation Time: 4,6, 8 days Result: Showed variation in antiproliferative effects across cancer cell lines Kuramochi, MDA-MB-468, NGP and NBL-S, with the most pronounced sensitivity observed in MDA-MB-468 cells.
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Dubiella C, et al. Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat Chem Biol. 2021;17(9):954-963.
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
