TVB-3664 Datasheet DC Chemicals

Description	TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.
Cat.No	DC39632
Name	TVB-3664

Chemical Properties

CAS	2097262-58-1
Formula	C25H23F3N4O2
MW	468.470936059952
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DM

References

[1]. Zaytseva YY, et al. Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Oncotarget. 2018 May 15;9(37):24787-24800. [2]. Heuer TS, et al. FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression. EBioMedicine. 2017 Feb;16:51-62.

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