2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
Target:
In Vivo
In Vitro
Tasisulam (200 μM-200 nM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam (200 μM-200 nM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Cell Proliferation Assay[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s are 10 μM and 25 μM, respectively. Cell Cycle Analysis[1] Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 μM Incubation Time: 72 hours Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced apoptosis in a broad range of in vitro cancer cell models.
Kinase Assay
Cell Assay
Animal Administration
References
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