Thiocolchicine. Datasheet DC Chemicals
Description Thiocolchicine is a potent tubulin polymerization and microtubule assembly inhibitor, a axonal cytoskeleton modulator and apoptosis inducer. Structurally, thiocolchicine is a colchicine analog in which the C-10 methoxy is replaced with a thiomethyl moiety. Thiocolchicine was shown to bind with high affinity to the colchicine site on tubulin (Ka = 1.07 +/- 0.14 x 10(6) M-1). Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.
Cat.No DC32494
Name Thiocolchicine.

Chemical Properties

CAS 2730-71-4
Formula C22H25NO5S
MW 415.50
Storage

References

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