Trofosfamide Datasheet DC Chemicals
Description Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis.
Cat.No DC31350
Name Trofosfamide

Chemical Properties

CAS 22089-22-1
Formula C9H18CL3N2O2P
MW 323.58418
Storage

References

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