UNC-0224 Datasheet DC Chemicals

Description	UNC-0224 is a potent inhibitor of G9a histone lysine methyltransferase (IC50 = 15 nM).
Cat.No	DC8293
Name	UNC-0224

Chemical Properties

CAS	1197196-48-7
Formula	C26H43N7O2
MW	485.67
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3. [2]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.

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