VX-702 (VX702) Datasheet DC Chemicals

Description	VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM.
Cat.No	DC1061
Name	VX-702 (VX702)

Chemical Properties

CAS	745833-23-2
Formula	C19H12F4N4O2
MW	404.3
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Kuliopulos A, et al. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb Haemost, 2004, 92(6), 1387-1393. [2]. Braddock M, IDDB Meeting Report, 2005, March 14-15. [3]. Gill A, IDDB Meeing Report, 2002, March 06-08. [4]. Naka K, et al. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2015 Aug 20;6:8039.

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