Lipidoid XMaN6 is an ionizable lipid with universality was screened
out from the adamantyl-based ionizable lipid series, which could
functionally deliver highly diverse types of nucleic acids. Among
them, the XMaN6 iLNPs were the best-delivering vectors.
XMaN6 was used to deliver mRNA, siRNA, pDNA, and cyclic
dinucleotide into different cells, including human primary
hepatocytes, HEK293T, Huh7, HepG2, and U2OS cell, with nontoxicity
after a single dose.The non-toxic XMaN6 lipidoid is highly versatile in entrapment and delivery of siRNA, mRNA, plasmid DNA, and a cyclic dinucleotide. XMaN6-based LNPs efficiently deliver: 1) siRNA into human primary hepatocytes and cell lines that are hard-to-transfect, 2) mRNA into mouse liver, 3) plasmid DNA, 4) 2′,3′-cGAMP into cells and activated the cGAS-STING pathway three orders of magnitude more efficiently than 2′,3′-cGAMP alone. To our knowledge, such universality in delivering different NA types has not been previously described and can accelerate translation of LNPs into the clinic.
Cat.No
DC88888
Name
Lipidoid XMaN6
Chemical Properties
CAS
Formula
MW
Storage
References
Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery-Hejdánková, Zuzana - Vaněk, Václav - Sedlák, František - Procházka, Jan - Diederichs, Audrey - Kereiche, Sami - Novotná, Barbora - Buděšínský, Miloš - Birkuš, Gabriel - Grantz Šašková, Klára - Cígler, Petr
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