A-1592668 Datasheet DC Chemicals
Description A-1592668 (A 1592668) is a novel potent, CDK9-selective inhibitor with IC50 of 1.2 nM, >1000 fold selectivity over CDK1/2/7/8; A-1592668 also displays selectivity of ~12- and 240-fold over CDK4 and CDK6 respectively. A-1467729 inhibited phosphorylation of RNA pol-II (p-RNA pol-II; Ser2) with a potency of 26.7 nM at the cellular level, inhibited MCL-1 dependent hematologic tumor cell lines H929 (IC50=39 nM) and MV4-11 (IC50=42.4 nM) following 24 h of incubation.
Cat.No DC70157
Name A-1592668

Chemical Properties

CAS 1628314-13-5
Formula C26H27F2N3O3
MW 467.517
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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