Acid-degradable Anionic Lipid (ADA) Datasheet DC Chemicals
Description
ADA (Acid-Degradable Anionic Lipids) is revolutionizing mRNA delivery with its unique azido-acetal linker, enabling rapid hydrolysis in endosomes (pH ~6.0). This breakthrough technology ensures efficient endosomal escape, significantly enhancing mRNA delivery to target cells. ADA-LNPs excel in delivering mRNA to the spleen and liver, making them ideal for immune-related therapies.By degrading into biocompatible byproducts, ADA minimizes long-term tissue persistence and toxicity.ADA-LNPs outperform traditional LNPs, delivering mRNA more effectively to immune cells like macrophages and B cells.
Cat.No
DC60639
Name
Acid-degradable Anionic Lipid (ADA)
Chemical Properties
CAS
Formula
C49H62LI3N5O11
MW
917.88
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
Acid-degradable lipid nanoparticles enhance the delivery of mRNA-Sheng Zhao, Aijun Wang, Niren Murthy,
Nat Nanotechnol 2024 Aug 23. -
Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein
Kai Chen, Hesong Han, Sheng Zhao, Bryant Xu, Boyan Yin, Atip Lawanprasert, Marena Trinidad, Benjamin W. Burgstone, Niren Murthy & Jennifer A. Doudna ---Nature Biotechnology (2024)
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