ADAM17 inhibitor SN-4 Datasheet DC Chemicals

Description	ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM.SN-4 showed slightly higher activity than the well-studied ADAM17 inhibitor marimastat.SN-4 inhibited the ability of ADAM17 to cleave tumor necrosis factor α (TNF-α) in vitro, inhibited cleavage of CD44 by ADAM17, but not by ADAM10, and to suppress cell invasion.
Cat.No	DC70174
Name	ADAM17 inhibitor SN-4

Chemical Properties

CAS
Formula	C23H32N4O3S3
MW	508.714
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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