α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
Cat.No
DC41803
Name
α-Conotoxin MII
Chemical Properties
CAS
175735-93-0
Formula
C67H103N23O22S4
MW
1710.94
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
[1]. G E Cartier, et al. A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors. J Biol Chem. 1996 Mar 29;271(13):7522-8.
[2]. S C Harvey, et al. Determinants of Specificity for Alpha-Conotoxin MII on alpha3beta2 Neuronal Nicotinic Receptors. Mol Pharmacol. 1997 Feb;51(2):336-42.
[3]. J M McIntosh, et al. Conus Peptides: Novel Probes for Nicotinic Acetylcholine Receptor Structure and Function. Eur J Pharmacol. 2000 Mar 30;393(1-3):205-8.
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