2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：127785-64-2 Product Name：Aureobasidin A (9CI) Synonyms：Aureobasidin A (9CI);10,12-tetradecanhexaenylidene]-3,5-dioxo,(2S,4E);2-[(2S)-4-[(2E,4E,6E,8E,10Z,12E)-11,13-dichlorotetradeca-2,4,6,8,10,12-hexaenoyl]-1-[(3S,4R,5R)-3-[(2S,3S,4R,5R)-5-[(2S,3S,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]oxy-3,4-dihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]-5-hydroxy-3-oxo-2H-pyrrol-2-yl]acetamide;AC1O52N9;aurantoside B;aureobasidin A;LY-295337;Basifungin;Aureobasidin A (AbA);Cyclo[L-Phe-N-methyl-L-Phe-L-Pro-L-aIle-N-methyl-L-Val-L-Leu-N-methyl-β-hydroxy-L-Val-[(3R)-D-Hmp-]-N-methyl-L-Val-] EINEC: Molecular Formula：C60H92N8O11 Molecular Weight：1101.41949653625
Target:
In Vivo
In Vitro
Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides[2].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. K Ikai, et al. Structure of aureobasidin A. J Antibiot (Tokyo). 1991 Sep;44(9):925-33.
[2]. Vanessa Cerantola, et al. Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol. 2009 Mar;71(6):1523-37.
[3]. K Kino, et al. Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins. FEBS Lett. 1996 Dec 9;399(1-2):29-32.
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