BFL-1 inhibitor 4E14 Datasheet DC Chemicals

Description	BFL-1 inhibitor 4E14 (4E14) is a potent, selective, covalent BFL-1 inhibitor that disrupt BH3-binding activity with IC50 of 1.3 uM, targets a unique C55 residue in the BFL-1 groove.4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.
Cat.No	DC70246
Name	BFL-1 inhibitor 4E14

Chemical Properties

CAS
Formula	C19H28N4O2S2
MW	408.579
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Edward P Harvey, et al. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6.

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