BI-0474 Datasheet DC Chemicals

Description	BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.
Cat.No	DC72237
Name	BI-0474

Chemical Properties

CAS	2750570-55-7
Formula	C30H37N9O2S
MW	587.738883733749
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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