BRM/BRG1 ATP Inhibitor-1 Datasheet DC Chemicals
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Cat.No DC46193
Name BRM/BRG1 ATP Inhibitor-1

Chemical Properties

CAS 2270879-17-7
Formula C11H9F3N4O2S
MW 318.274970769882
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：2270879-17-7
Product Name：BRM/BRG1 ATP Inhibitor-1
Synonyms：BRM/BRG1 ATP Inhibitor-1;1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea;TQR0285;Dual BRM and BRG1 inhibitor 14;BDBM50469330
EINEC:
Molecular Formula：C11H9F3N4O2S
Molecular Weight：318.274970769882
Target: IC50: ﹤0.005 µM (BRM, BRG1)[1]
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
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