c-Di-AMP(Cyclic-Di-AMP) ammonium salt Datasheet DC Chemicals
Description
Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation.
Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2].
Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3].
Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5].
Cat.No
DC28012
Name
c-Di-AMP(Cyclic-Di-AMP) ammonium salt
Chemical Properties
CAS
54447-84-6
Formula
C20H24N10O12P2
MW
658.41
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
[1]. Ren A, et al. c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets. Nat Chem Biol. 2014 Sep;10(9):780-6.
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