Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. c-di-GMP also has functions in eukaryotic cells. It is detected by the transmembrane protein stimulator of interferon genes (STING), leading to activation of the innate immune system.
Cat.No
DC28013
Name
Cyclic-di-GMP(c-di-GMP)
Chemical Properties
CAS
61093-23-0
Formula
C20H24N10O14P2
MW
690.41
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMS
References
[1]. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57.
[2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.
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