CAF01 (Cationic Adjuvant Formulation 01) Datasheet DC Chemicals
Description
CAF01 (Cationic Adjuvant Formulation 01) is a lipid-based adjuvant system comprising cationic liposome dimethyldioctadecylammonium bromide (DDA) and immunomodulator trehalose 6,6'-dibehenate (TDB). It enhances antigen-specific immune responses, particularly Th1-type cellular immunity, by stabilizing cationic liposomes for antigen delivery and activating innate immunity via TDB's interaction with receptors like Mincle.
CAF01 has shown promise in vaccine development, especially for tuberculosis, by boosting immunogenicity and inducing durable immune memory. Its proven safety and biocompatibility in clinical trials support its potential for human vaccine applications. In summary, CAF01 is a versatile and effective adjuvant, offering robust immune enhancement for novel vaccine strategies.
Cat.No
DC67250
Name
CAF01 (Cationic Adjuvant Formulation 01)
Chemical Properties
CAS
Formula
MW
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
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