Canakinumab Datasheet DC Chemicals

Description	Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.
Cat.No	A235
Name	Canakinumab

Chemical Properties

CAS	914613-48-2
Synonyms	Canakinumab;Anti-Human IL-1B(Canakinumab);Research Grade Canakinumab(DHB95601);Ilaris; ACZ 885
pH value	Corresponds to reference standard: PASS
Non-reduced CE-SDS	>95%
SEC-HPLC	>95%
Isoelectric Point	Corresponds to reference standard
Bacterial Endotoxins Test
Residual Proteins of Host Cell
Exogenous Residual DNA
Residual protein A
Biological Activity
Osmolality	Corresponds to reference standard: PASS
Peptide mapping	Corresponds to reference standard: PASS
N-terminal sequence	Corresponds to reference standard: PASS

References

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