Carotegrast methyl free base Datasheet DC Chemicals
Description Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer's patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice.
Cat.No DC75163
Name Carotegrast methyl free base

Chemical Properties

CAS 401905-67-7
Formula C28H26CL2N4O5
MW 569.43
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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