CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 was highly selective toward liver parenchymal cell in vivo.Multitail lipids usually have three or more tails and tend to form
more cone-shaped structures due to the increase of tail crosssection,
which enhances the endosome escape and mRNA
delivery efficiency.CKK-E12 is an ionizable lipid with four
lipid tails and diketopiperazine core-based head. It has shown
excellent efficiency in delivering CRISPR-Cas9 mRNA and
sgRNA.cKK-E12 iLNPs encapsulated mRNA was used to
investigate the effect of Toll-like receptor 4 (TLR4) on iLNPsmediated
mRNA delivery, and it has been demonstrated that
the targeting, safety and efficacy of iLNPs are closely related
to disease state. In other words, even though iLNP delivers
therapeutic mRNA to a given cell type in one disease state, it
is not guaranteed to deliver mRNA to the same cell type in
another disease. As same as MC3 and C12-200, CKK-E12 is also
used to be a positive control ionizable lipid when exploiting new
ionizable lipids.
Cat.No
DC49882
Name
CKK-E12
Chemical Properties
CAS
1432494-65-9
Formula
C60H120N4O6
MW
993.62
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
[1]. Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753]. Proc Natl Acad Sci U S A. 2014;111(11):3955-3960.
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