COH34 Datasheet DC Chemicals
Target Home > Products > Featured products
Cat.No DC42744
Name COH34

Chemical Properties

CAS 906439-72-3
Formula C18H15NOS
MW 293.38
Storage 0°C (short term), -20°C (long term), desiccated

Biological activity

Description CAS NO.：906439-72-3
Product Name：(E)-1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol
Synonyms：COH34; COH-34; COH 34
EINECS:
Molecular Formula：C18H15NOS
Molecular Weight：293.38
Target: IC50: 0.37 nM (PARG)[1]
In Vivo COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].
In Vitro COH34 efficiently kills PARP inhibitor-resistant cancer cells[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
Tel: +86-21-58447131
Fax: +86-21-61642470

Email:
sales@dcchemicals.com
order@dcchemicals.com

Website:
www.dcchemicals.com