PROTAC NTRK1 degrader-1 Datasheet DC Chemicals

Description	NTRK degrader-1 is a wild-type and mutant NTRK1 PROTAC degrader with IC50 values of 4 nM (wild-type), 2 nM (G595R), 5 nM (G667C), and <0.5 nM (F598L). NTRK degrader-1 catalyzes ubiquitination and subsequent proteasome-mediated degradation of wild-type and mutant (G595R, G667C, F598L) NTRK1.NTRK degrader-1 can be used for the research of solid tumors. (Pink: NTRK1 Target protein ligand; Blue: Cereblon E3 ligase ligand; Black: linker).
Cat.No	DC81390
Name	PROTAC NTRK1 degrader-1

Chemical Properties

CAS	2858741-81-6
Formula	C17H19FN2O3
MW	318.35
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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