CU-115 Datasheet DC Chemicals

Description	CU115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU 115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells.
Cat.No	DC42507
Name	CU-115

Chemical Properties

CAS	2471982-20-2
Formula	C21H11F7INO2
MW	569.21
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1]. Rosaura Padilla-Salinas, et al. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62(22):10221-10244.

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