2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：2408590-37-2 Product Name： Synonyms： EINEC: Molecular Formula：C22H18CL4N6O3 Molecular Weight：556.228720188141
Target:
In Vivo
CWI1-2（5 mg/kg，i.v.，每日一次，7-10天）hydrochloride 可显着延缓 BMT 受体 B6.SJL（CD45.1）小鼠白血病的发生和存活时间，体重无明显影响 [1]。
In Vitro
CWI1-2 (0-1 μM, 24 h) hydrochloride 具有良好的抗白血病功效[1]。 Apoptosis Analysis[1] Cell Line: MonoMac6, MOLM13 Concentration: 0-1 μM Incubation Time: 24 h Result: Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells. Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells. Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10.
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
