Cyclo(-RGDfK) Datasheet DC Chemicals
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Cat.No DC8055
Name Cyclo(-RGDfK)

Chemical Properties

CAS 161552-03-0
Formula C27H41N9O7
MW 603.67054
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：161552-03-0
Product Name：Cyclo(-RGDfK)
Synonyms：cyclo (Arg-Ala-Asp-d-Phe-Lys);2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;c(RGDfK);cyclo (Arg-Gly-Asp-d-Phe-Lys),c(RGDfK);CYCLO (RGDFK);Cyclo (-RGDfK);Cyclo(-Arg-Gly-Asp-D-Phe-Lys);Cyclic RGDfK peptide;cyclo (Arg-Gly-Asp-d-Phe-Lys);Cyclo(RGDfK) peptide;Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl);CYCLO(-RGDFK);cyclo (Arg-Gly-Asp-Phe-Lys);Cyclo(-Arg-Gly-Asp-D-Phe-Lys) Trifluoroacetate salt;Cyclo(-RGDfK)
EINEC:
Molecular Formula：C27H41N9O7
Molecular Weight：603.67054
Target:
In Vivo
In Vitro Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].
Kinase Assay
Cell Assay
Animal Administration

References

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