DSPE-PEG-DBCO is a kind of highly active phospholipid PEG derivative which can react with azide group. DBCO (dibenzocycloctene) is a commonly used copper-free click chemical with rapid and specific reactivity to molecules containing azides (-N3). DBCO-PEG derivatives have fast kinetics and good stability in aqueous buffers. The reaction between DBCO and the azide group allows DSPE to label and bind to the target substrate efficiently. DSPE (1, 2-distearoyl-SN-glycerol-3-phosphate ethanolamine) is a highly hydrophobic 18-carbon saturated phospholipid. Pegylated phospholipids are excellent liposomal preparation materials, which can be used for molecular encapsulation, gene transfection and drug delivery. Copper-free chemical reaction with easily synthesized diaryl azacycloctanone. Reactions of azide compounds with tense alkynes, such as cyclocycloalkynes, easily form triazole compounds without the need for toxic catalysts.
Cat.No
DC66275
Name
DSPE-PEG-DBCO
Chemical Properties
CAS
Formula
MW
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
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