DU011 Datasheet DC Chemicals
Description DU011 is a noncanonical anti-infective agent and small-molecule inhibitor of capsule biogenesis, targets MprA (Kd=30 nM), a MarR family transcriptional repressor of multidrug efflux pumps, inhibits capsule expression in E. coli. DU011 does not alter Escherichia coli antibiotic resistance and has significantly enhanced inhibition of capsule expression, compared with other proposed MprA ligands, such as salicylate and 2,4-dinitrophenol (DNP).
Cat.No DC70368
Name DU011

Chemical Properties

CAS 890818-51-6
Formula C20H15F2NO4S
MW 403.400
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Arshad M, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01208-20.
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