DX314 Datasheet DC Chemicals
Description DX314 is a potent, specific CYP26B1 inhibitor with IC50 of 108 nM, >15-fold selectivity over CYP26A1.DX314 potentiates all-trans-RA (atRA) gene expression effects in healthy and diseased reconstructed human epidermis (RHE).DX314 potentiates the effects of atRA on the expression and localization of keratin 10 (KRT10), protects barrier function in RHE.DX314 reduces comedonal number, induces epidermal thickening, and increases comedonal profile, while having no effect on transepidermal water loss (TEWL) in treated rhino mice.
Cat.No DC70373
Name DX314

Chemical Properties

CAS 1662711-07-0
Formula C25H29NO3
MW 391.511
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Joachim G S Veit, et al. J Invest Dermatol. 2021 Jan;141(1):72-83.e6
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