Endosidine 5 (ES5), is one of the most potent small molecules interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm. The delivered mRNAs is greatly enhanced via inhibition of endocytic recycling in cells and in live mice. NAV2729 (NAV) and endosidin 5 (ES5), resulted in significant enhancement (1.5–2 folds) of LNP-mediated delivery of Fluc mRNAs. Incubation of NAV and ES5 together caused modest further increases in Fluc expression in comparison to the sole application of either compound.
Cat.No
DC60580
Name
Endosidin5(ES5)
Chemical Properties
CAS
Formula
C20H18N4
MW
314
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
Targeting Recycling Endosomes to Potentiate mRNA Lipid Nanoparticles-Nano Lett. 2024 May 1;24(17):5104-5109. doi: 10.1021/acs.nanolett.3c04415. Epub 2024 Apr 19.
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