ERD-1233 is a potent and orally efficacious estrogen receptor α (ERα) degrader with DC50 of 0.9 nM. ERD-1233 does not display any liability in CYP inhibition, hERG inhibition, and microsomal and plasma stability. ERD-1233 effectively reduces ER protein in ER+ tumors and achieves tumor regression in the ER wild-type MCF-7 xenograft tumor model.
ERD-1233 is a potent and orally efficacious estrogen receptor α (ERα) degrader with DC50 of 0.9 nM. ERD-1233 does not display any liability in CYP inhibition, hERG inhibition, and microsomal and plasma stability. ERD-1233 effectively reduces ER protein in ER+ tumors and achieves tumor regression in the ER wild-type MCF-7 xenograft tumor model.
Cat.No
PR0047243
Name
ERD-1233
Chemical Properties
CAS
Formula
MW
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
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