F5446 Datasheet DC Chemicals

Description	F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.
Cat.No	DC42710
Name	F5446

Chemical Properties

CAS	2304465-89-0
Formula	C26H17CLN2O8S
MW	552.94
Storage	0°C (short term), -20°C (long term), desiccated

References

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