GEM144 Datasheet DC Chemicals

Description	GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts.
Cat.No	DC71179
Name	GEM144

Chemical Properties

CAS	2487526-28-1
Formula	C28H31NO5
MW	461.55
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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